Plasmid Manufacturing

Industrial Leading Timeline

Guaranteed Quantity and Quality

Plasmid can be an ideal vector for CGT, mRNA and DNA vaccines. Variations in structure, promoters, and copy numbers, etc.will be challenging in scale-up manufacturing. ProBio is dedicated to produce plasmid DNA with advanced technologies from preclinical to commercial stages.

Explore with our expert team

• Industrial Leading Timeline

  • Fast turnaround to meet your demanding timeline
    • Plasmid for early clinic: as fast as 4 weeks from cell bank to batch release
    • Plasmid for late clinic & commercial: as fast as 12 weeks from cell bank to batch release

• Guaranteed Delivery

  • Guaranteed plasmid quantity and quality – no surprises or hidden costs
  • Dual plasmid manufacturing in US and CN for resilient supply chain and risk mitigation

• Application-specific Solution

  • Ultra small scale ( 50 mg~200mg) plasmid offering for early-phase trial with no excess waste
  • Excellent ITR integrity (>90%) with proprietary PowerS™-ITRrs strain for AAV transfer plasmid
  • High performing PowerS™-DNA⁺ strain for DNA vaccine with up to 2.5g/L

Phase-appropriete Plasmid Manufacturing Service

• GMPro™ grade: cost-effective adoption of relevant GMP manufacturing features
• GMP grade: highest quality, full GMP environment for late clinical and commercial stages

IND

Phase I

Phase II

Phase III

BLA

Commercial

IND CMC

GMPro^TM Grade

GMP Grade

BLA PC/PV

GMP Grade

Proprietary Strains for Various Downstream Applications

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  Proprietary PowerS™-ITRrs Strain for AAV Transfer Plasmid

• 

  Proprietary PowerS™-DNA⁺ Strain for DNA Vaccine

Related Service

• LentiHelper^TM Plasmid Products
• Linearized DNA Manufacturing
• Plasmid CMC
• PowerS^TM-ITRrs Strain
• LVV BLA PC/PV