GMP LVV Manufacturing Service

Proprietary Suspension Cell Line PowerS^TM-293T

Comprehensive Quality Assurance

GMP LVV Manufacturing Service

With the rapid development, more and more programs that using lentiviral vectors (LVV) have finished clinical trials, and been ready for commercialization. ProBio has worked with global customers and is able to provide GMP LVV from clinical phases to commercialization in both adherent and suspension cultures, starting from either cell bank or plasmid manufacturing plasmid manufacturing.

Join us – together, we can achieve more!

Overview of GMP LVV Manufacturing Workflow

ProBio is experienced in manufacturing lentiviral vectors adopting both adherent production system and suspension production system. We use HEK293T cell lines, and developed our proprietary suspension cell line PowerS^TM-293T, with the production capacity from 2L to 200L.

Our experts will discuss your project with you in detail and propose a best solution to accelerate your project.

IND

Phase I

Phase II

Phase III

BLA

Pre-Clinical

Commercial

Pro Grade

IND CMC

Clinical GMP Grade

GMP Grade

BLA PC/PV

GMP Grade

• Suspension Culture System
• Adherent Culture System

Suspension Culture System

• Proprietary cell line PowerS^TM-293T
• Stable and scalable suspension manufacturing process
• up to 200L manufacturing scale
• 4~5 times final yield improvement comparing with adherent culture system
• ~50% cost reduction
• High T cell transduction efficiency

PowerS^TM-293T

• Proprietary Suspension cell line
• License for IND, clinical and commercial
• Royalty free, maintenance free
• Excellent performance in producing lentiviral vector

LVV Production: PowerS^TM-293T with Different GOI

Titer over 10⁷ TU/ml

Adherent Culture System

• The largest manufacturing scales is Up to 96L
• Closed culture system reduces contamination and improves stability
• Full-automatic operation improves reproducibility and stability

Accumulated Experience

ProBio has accumulated rich experience in manufacturing lentiviral vector, which guaranteed a dedicated and professional service for customers.

• Worked with global clients for their LVV projects
• Provided GMP lentiviral vector for CAR-T, TCR-T projects
• Over 100 GMP manufacturing batches experience

Related Services

• Lentiviral Vector One-stop Solution
• Plasmid CDMO Sevices
• LVV BLA PC/PV