Fc Engineering Service

The highlight of STR silencing technology:

• STR silencing technology comprises 3 mutations in the CH2 domain of the Fc.
• STR silencing technology truly abolish Fc domain effector function whereas other Fc silencing technologies, such as LALA or glycosylation only reduce but do not abolish Fc receptor binding.
• STR silencing technology can be applied to any IgG based antibody or other Fc-fusion protein.

• Fc domain binding to Fc receptors mediates the different antibody effects, such as ADCC and ADCP effects by FcγRs, CDC effects by C1q, and FcRn is associated with the half-life of proteins.

  The enhancement of Fc region-mediated effector functions, for instance, ADCC or ADCP effects enhanced by the affinity of the Fc domain to the FcγRIII(CD16), improves antibody efficacy.

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ProBio provides multiple Fc engineering solutions for ADCC, CDC, and ADCP enhancement.

• IgG recycling begins with IgG binding to the FcRn with IgG uptake into an endothelial cell via an acidified endosome. It ultimately ends up with the release of IgG back into the blood. Enhancement of the binding between IgG & FcRn will promote a higher ratio of IgG recycling and improve the antibody serum half-life.

  ProBio provides two strategies to elongate antibody serum half-life: FTO mutants, Library screening for novel Fc mutation.

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