Home » Biologics Discovery » Antibody Lead Optimization

Antibody Lead Optimization Service

Experience with 500+ antibody optimization projects
Accelerating the acquisition of "me-better" antibody candidates

The functionality and developability properties of therapeutic antibodies are two major concerns in preclinical development. Addressing the optimization strategy in the discovery stage enables acquiring better antibody candidates before entering CMC.

Empowered by a well-established bioinformatics platform, ProBio offers customers comprehensive antibody engineering services, including humanization, affinity maturation, Fc engineering, and developability optimization, to obtain "me-better" antibody leads.

ProBio offers 3 developability assessment packages for antibody drug candidates at different discovery stages to identify the potential risks of manufacture and clinical failure.

500+

Antibody humanization project experience
2.5 weeks

Deliver desired humanized antibody
10-100 fold

Guarantee affinity improvement
Marketed

The most advanced project

By Jan.2024

Antibody Lead Optimization Service

Two major considerations in the preclinical development of antibody drugs: functionality and developability

- Developability
  - Antibody Humanization
  - Developability Assessment
  - ✔ In silico developability analysis
  - ✔ In vitro developability assay
  - ✔ Manufacturability assessment
  - Developability Optimization
  - ✔ Aggregation optimization
  - ✔ Post-Translational Modification (PTM) optimization
- Functionality
  - Antibody affinity maturation
  - Fc engineering
  - ✔ Enhance effector function
  - ✔ Reduce effector function
  - ✔ Increase half-life

Bioinformatics

Extensive bioinformatics tools, including multiple databases and MOE(Molcular Operationg Environment), an integrated computer-aided molecular design platform.