Pre-clinical DMPK Study and Generation of Toolbox to Facilitate PK/ADA Analysis

• Speaker: Derek Chen, Sr. Director, Antibody Drug Discovery Dept.
• Date: Feb 25^th, 2025
• Time:13:30-14:30 (GMT+8)

Biography

Dr. Derek Chen is the Sr. Director of Antibody Drug Discovery Department of ProBio. After obtaining his doctorate in immunology from the University of Massachusetts School of medicine, he joined GenScript in 2015 and has been responsible for antibody drug discovery platform for the past seven years. He has more than 200 project experience in antibody drug discovery and Engineering innovation optimization, as well as three patents related to biopharmaceutical discovery.

Topic Background

Animal based DMPK analysis is a crucial component in pre-clinical study of drug candidate. It provides preliminary insight into the drug metabolism and pharmacokinetics, and help to evaluate the risk of developability. To facilitate the analysis of biological samples, reagent antibody, such as anti-idiotype Ab, becomes Indispensable tools. In this talk, we will introduce the DMPK service offered by ProBio, and discuss the generation and application of reagent antibodies for PK study.

Topic Abstract

• General introduction of DMPK services by ProBio
• Generation of anti-idiotype antibody for PK study
• Generation and application of universal PK tool antibody